Table 3.
Comparison of in vitro QN sensitivity among Plasmodium falciparum with different pfmdr1and pfnhe-1 genotypes
| Parasite genotypes | No. (%) | Mean QN IC50 | p value | |
|---|---|---|---|---|
| (nM) | ||||
| pfmdr1 | ||||
| 86 | N86 | 70 (82.4) | 216.5 ± 127.5 | 0.025* |
| 86Y | 15 (17.6) | 138.3 ± 76.1 | ||
| 184 | Y184 | 32 (37.7) | 160.4 ± 93.6 | 0.013* |
| 184F | 53 (62.3) | 228.3 ± 132.6 | ||
| 1034 | S1034 | 71 (83.5) | 194.1 ± 114.0 | 0.144 |
| 1034C | 14 (16.5) | 246.9 ± 160.5 | ||
| 1042 | N1042 | 68 (80) | 185.8 ± 113.8 | 0.010* |
| 1042D | 17 (20) | 270.5 ± 139.9 | ||
| Copy no. | <3 | 69 (81.2) | 195.8 ± 132.2 | 0.284 |
| ≥ 3 | 16 (18.8) | 232.7 ± 68.8 | ||
| pfnhe-1 | ||||
| DNNND repeats | 0 | 1 (1.2) | 183.6 | 0.958 |
| 1 | 3 (3.7) | 246.1 ± 147.1 | ||
| 2 | 5 (6.2) | 163.7 ± 44.2 | ||
| 3 | 26 (32.1) | 203.0 ± 155.3 | ||
| 4 | 39 (48.2) | 213.0 ± 108.6 | ||
| 5 | 7 (8.6) | 195.9 ± 92.0 | ||
| DDNNNDNHNDD repeats | 0 | 3 (3.7) | 115.7 ± 71.3 | 0.049** |
| 1 | 14 (17.3) | 272.6 ± 193.1 | ||
| 2 | 64 (79.0) | 195.8 ± 102.4 | ||
| NHNDNHNNDDD repeats | 0 | 9 (11.1) | 196.4 ± 137.6 | 0.378 |
| 1 | 70 (86.4) | 210.8 ± 124.2 | ||
| 2 | 2 (2.5) | 87.0 ± 47.4 | ||
* Significant difference determined by Independent t test
* Significant difference determined by One-way ANOVA