Skip to main content
. 2012 Feb 27;7(2):e31124. doi: 10.1371/journal.pone.0031124

Figure 1. Intrinsic excitability of hippocampal neurons is not altered in adult NesCreIrs2KO mice.

Figure 1

A–B: Neither resting membrane potential (RMP; A) or membrane resistance (Input Resistance; B) showed significant differences between CA1 pyramidal neurons of NesCreIrs2KO mice (−/−; −67±6 mV; 229±17 MΩ, N = 11, n = 20) and littermate controls (+/+; −67±5 mV; 248±27 MΩ, N = 14, n = 22). C: A similar number of action potentials were generated in response to 1 s-long current injections to CA1 neurons of control (+/+; 160 pA: 3.1±0.7; 200 pA: 4.1±0.8; 240 pA: 4.4±0.7) and NesCreIrs2KO (−/−; 160 pA: 2.8±0.5; 200 pA: 4.1±0.6; 240 pA: 5.2±0.8) mice. D: Sample traces taken from representative experiments in CA1 neurons of control (+/+; RMP: −58 mV) and NesCreIrs2KO (−/−; RMP: −60 mV) mice, illustrate the response to a 1 s-long injection of 200 pA. Scale bars: 20 mV, 200 ms.