Table 1. Selectivity of compounds against a panel of PTPs.
PTPs | IC50 (µM) | ||
(+)-Rutamarin | Compound-2 | Pervanadate | |
PTP1B | 6.4 | 5.5 | 0.015 |
PTPα | NI* | NI* | 0.059 |
LAR | NI* | NI* | 0.026 |
CD45 | >100 | NI* | 0.006 |
TC-PTP | 26.8 | 33.9 | 0.036 |
* NI: No inhibition at 100 µM.