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. 2012 Feb 27;7(2):e32099. doi: 10.1371/journal.pone.0032099

Figure 5. The SzP/TRX interaction facilitated S. zooepidemicus to avoid being phagocytized.

Figure 5

The phagocytosis percentage of Raw264.7 wild strain and TRXi strain did not differ significantly. The S. zooepidemicus SzP-knockout strain were phagocytized effectually. In the presence of the serum, the antiphagocytosis of S. zooepidemicus was more pronounced with the SzP/TRX interaction, as there was significantly more macrophage containing ingested S. zooepidemicus in TRXi Raw264.7 cells than the wild type Raw264.7 cells. Thus, the SzP/TRX interaction reduced the phagocytosis of S. zooepidemicus by the macrophages in the host immune system. The phagocytosis percentage of the TRX pretreated S. zooepidemicus wild strain was significantly lower than the SzP-knockout strain in the TRXi Raw264.7 cells. In the absence of the serum, the phagocytosis of the macrophages was independent of TRX, and only SzP was able affect phagocytosis (n = 3, mean±SD, ** p<0.01).