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(A) Effect of overexpression of the ITPA and the gene encoding yeast ITPase, HAM1, on HAP-induced apoptosis in HeLa cells. Differences are significant (*p<0.05, **p<0.01). (B) Overexpression of the yeast HAM1 could rescue ITPA knockdown cells from hypersensitivity to HAP-induced apoptosis (****p<0.0001, n.s., not significant).
