Figure 6. 129 mouse α-defensins exhibit diminished antimicrobial activity against pro-inflammatory E. coli strains.

(A) AU-PAGE was used to generate α-defensin profiles from B6 and 129 mice. The α-defensin region was excised and overlaid onto E.coli-laden agarose. (B) Zones of bacterial inhibition were detected for both NC101 (upper) and LF82 (lower) E. coli strains. Increased growth inhibition was consistently observed from α-defensins from B6 mice.