Figure 2.
Human adrenal steroid biosynthetic pathways illustrating the three main products of the human adrenal cortex: aldosterone, cortisol, and adrenal androgens (DHEA, DHEA-S) as well as the enzymes that synthesize these steroids. StAR = steroidogenic acute regulatory protein; CYP11A1 = cholesterol side-chain cleavage enzyme; HSD3B2 = 3 beta-hydroxysteroid dehydrogenase type II; CYP21 = 21-hydroxylase; CYP11B1 = 11-beta-hydroxylase; CYP11B2 = aldosterone synthase; CYP17 = 17-alpha-hydroxylase/17, 20 lyase; SULT2A1 =Steroid-sulfotransferase.