Figure 3.
Heatmap of CCNB2, IL13A2, SLC16A9, HTR2B and RARRES2 genes in human PRKAR1A, SW13, H295 cell strains, HAC15 cells, primary adrenal cells and normal adrenal tissue based on microarray analysis. CCNB2, IL13A2 were expressed at higher level while SLC16A9, HTR2B and RARRES2 were expressed at lower level in most of the cell lines compared with the human normal adrenal tissue or primary culture of adrenal cells. The expression of these genes in cell lines showed a consistency with its expression in malignant adrenocortical tumor according to Fernandez-Ranvier et al. study(Fernandez-Ranvier et al., 2008). The color of heatmap indicates the expression value of each gene in the corresponding sample, and is based on the bar in the lower right-hand corner. PAC=primary adrenal cells; NA= normal adrenal tissue.