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. Author manuscript; available in PMC: 2013 Feb 15.
Published in final edited form as: Cancer Res. 2011 Dec 20;72(4):917–927. doi: 10.1158/0008-5472.CAN-11-1620

Figure 4.

Figure 4

Lag3−/−Pdcd1−/− mice develop lethal systemic autoimmunity. (A) Disease incidence for Lag3−/−Pdcd1−/− mice, plus single knockout and WT littermate controls. Moribund curves were analyzed for statistical significance by logrank test- *** p<0.001. (B) Representative histopathology of the heart and pancreas of WT and Lag3−/−Pdcd1−/− mice. (C) Number of various T cell populations in the spleen and LNs (inguinal and brachial) is shown. Data represent three to four independent experiments with 4-7 mice total per group (5-7 weeks old). Error bars represent SEM - * p<0.05, ** p<0.01 (unpaired t-test).