Table 5.
Results of multivariate analyses for overall survival, leukemia-free survival, relapse and treatment-related mortality among recipients of unrelated donor transplantation
| Variable | Hazard ratio* | 95% confidence intervals |
P-value |
|---|---|---|---|
| Overall survival† | |||
| Age at transplant, years | |||
| Children | 1.0 | - | <0.01‡ |
| Adolescent and young adults | 1.33 | 1.18-1.50 | <0.01 |
| Older adults | 1.43 | 1.26-1.62 | <0.01 |
| Year of transplant | |||
| 1989-1997 | 1.0 | - | <0.01 |
| 1998-2005 | 0.74 | 0.67-0.81 | |
| Leukemia-free survival§ | |||
| Age at transplant, years | |||
| Children | 1.0 | - | <0.01‡ |
| Adolescent and young adults | 1.22 | 1.08-1.38 | <0.01 |
| Older adults | 1.28 | 1.14-1.45 | <0.01 |
| Year of transplant | |||
| 1989-1997 | 1.0 | - | <0.01 |
| 1998-2005 | 0.80 | 0.73-0.87 | |
| Relapse∥ | |||
| Age at transplant, years | |||
| Children | 1.0 | - | 0.03‡ |
| Adolescent and young adults | 0.80 | 0.68-0.95 | 0.01 |
| Older adults | 0.90 | 0.76-1.05 | 0.18 |
| Year of transplant | |||
| 1989-1997 | 1.0 | - | 0.10 |
| 1998-2005 | 1.13 | 0.98-1.30 | |
| Treatment-related mortality¶ | |||
| Age at transplant, years | |||
| Children | 1.0 | - | <0.01‡ |
| Adolescent and young adults | 1.83 | 1.53-2.18 | <0.01 |
| Older adults | 1.90 | 1.58-2.29 | <0.01 |
| Year of transplant | |||
| 1989-1997 | 1.0 | - | <0.01 |
| 1998-2005 | 0.57 | 0.51-0.64 |
Hazard ratios refer to hazards of death or relapse
Other variables significantly associated with overall survival included race/ethnicity, cytogenetic risk at diagnosis, disease status at transplant, time from diagnosis to transplant and performance status score at transplant (also see Appendix Table 4)
Overall P-value, 2 degrees of freedom test
Other variables significantly associated with leukemia-free survival included cytogenetic risk at diagnosis, disease status at transplant, time from diagnosis to transplant and performance status score at transplant (also see Appendix Table 4)
Other variables significantly associated with relapse included cytogenetic risk at diagnosis, disease status at transplant, time from diagnosis to transplant and performance status score at transplant (also see Appendix Table 4)
Other variables significantly associated with treatment-related mortality included race/ethnicity, disease status at transplant and performance status score at transplant (also see Appendix Table 4)