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. Author manuscript; available in PMC: 2013 Feb 15.
Published in final edited form as: Cancer Res. 2011 Dec 21;72(4):979–989. doi: 10.1158/0008-5472.CAN-11-2579

Figure 6. The synergistic effects of AZD7762 and LMP-400 in a panel of colon carcinoma cell lines is independent of Chk2.

Figure 6

A) HCT15 cells complemented with wild-type Chk2 (HCT15 Chk2 WT), kinase-dead Chk2 (HCT15 KD) were treated with LMP-400 alone or in combination with various fixed concentrations of AZD7762 for 48 h. B) Graph of CI (combination Index) values vs Fa (Fraction affected) for data points shown in panel A on the combination (AZD7762 + LMP-400) for HCT15 cells. C) wild-type HCT116 (HCT116 WT) and Chk2 knockout HCT116 cells (HCT116 Chk2 −/−) were treated with LMP-400 alone or in combination with various fixed concentrations of AZD7762 for 48 h. D) Graph of CI (combination Index) values vs Fa (Fraction affected) for data points shown in panel C on the combination (AZD7762 + LMP-400) for HCT116 cells. Cell survival was assessed by MTS assays. Data represent mean ± S.E. of three independent experiments.