Skip to main content
. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Dev Biol. 2011 Dec 22;363(1):74–83. doi: 10.1016/j.ydbio.2011.12.024

Figure 7.

Figure 7

Nodal suppresses the expression of zfhx1/z81 on the oral side of the animal plate. (A) The expression pattern of zfhx1/z81 (magenta) in the animal plate of control (glycerol-injected) embryos is marked by foxQ2 (green) expression. A square shows the region magnified in (B). Animal pole view. (B) zfhx1/z81 is expressed in cells along the aboral edge of the animal plate. (C) zfhx1/z81 is expressed all around the circumference of the animal plate in Nodal morphants (asterisks). (D) zfhx1/z81 is not expressed in Lefty or BMP morphants, in which Nodal expression extends around the animal plate (E). (F) Schematic illustrating that Nodal suppresses the differentiation of serotonergic neurons on the oral side of the animal plate. (G) The expression pattern of tph in the control (glycerol-injected) embryo (green). Oral view. (H) tph is radially expressed in the animal plate in Nodal morphants. Animal pole view. (I, J) tph is not expressed in either Lefty or BMP morphants.