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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Mucosal Immunol. 2011 Nov 16;5(2):121–128. doi: 10.1038/mi.2011.56

Figure 5. Enhanced production of pro-inflammatory cytokines by foreskin CD8+ T cells.

Figure 5

PBMC and foreskin cells from 46 men were either left unstimulated (vehicle) or treated with PMA-ionomycin. Cells were then stained with CD3-FITC, CD8-PerCP, TNFα-PE and IFNγ-APC. Plots in (A) were created by gating on CD3+/CD8+ events. The gates defining TNFα + and IFNγ+ events were created based on unstimulated PBMC staining for each patient, and then applied to stimulated PBMC and foreskin plots. (B) Proportions of CD8 T cells producing TNFα, (C) IFNγ, and (D) of bi-functional CD8 T cells (producing both TNFα and IFNγ).