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. Author manuscript; available in PMC: 2013 Mar 1.

Published in final edited form as: Mitochondrion. 2011 Oct 1;12(2):248–257. doi: 10.1016/j.mito.2011.09.011

Fig. 4 — Effect of Coenzyme Q supplementation on kd/kd Motor Activity.

(a) Coenzyme Q (CoQ) treated B6.Pdss2_kd/kd (kd/kd) mice showed no significant changes in performance on the rotarod when compared to untreated kd/kd controls (p>0.05). Data points represent mean +/− S.E.M. for each day of testing, assessment at each timepoint involved three trials per day over three consecutive days. Ages at each time point (TP) are as follows: TP1: 14 weeks, TP2: 17 weeks, TP3: 19 weeks. (b) Coenzyme Q (CoQ) treated kd/kd mice showed no significant changes in locomotor activity when tested using the “home cage” activity monitoring system (MedAssociates) in comparison with untreated kd/kd animals (p>0.05). Ambulations are reported as mean +/− S.E.M. (arbitrary units) in 5-minute intervals for a total testing period of 30 minutes. (c) kd/kd mice with dietary probucol supplementation showed no significant changes in performance on the rotarod when compared to untreated kd/kd controls (p>0.05). Data points represent mean +/− S.E.M. for each day of testing, assessment at each timepoint involved three trials per day over three consecutive days. Ages at each timepoint (TP) are as follows: TP1: 17 weeks, TP2: 19 weeks. (d) Probucol treated kd/kd mice showed no significant changes in locomotor activity when tested using the “home cage” activity monitoring system in comparison with untreated kd/kd animals. Ambulations are reported as mean +/− S.E.M. (arbitrary units) in 5-minute intervals for a total testing period of 30 minutes. Statistical analyses were performed using two-way ANOVA followed by Bonferroni-Dunn post-hoc tests. N values denote animal group size.

Fig. 4 — Effect of Coenzyme Q supplementation on kd/kd Motor Activity.

(a) Coenzyme Q (CoQ) treated B6.Pdss2_kd/kd (kd/kd) mice showed no significant changes in performance on the rotarod when compared to untreated kd/kd controls (p>0.05). Data points represent mean +/− S.E.M. for each day of testing, assessment at each timepoint involved three trials per day over three consecutive days. Ages at each time point (TP) are as follows: TP1: 14 weeks, TP2: 17 weeks, TP3: 19 weeks. (b) Coenzyme Q (CoQ) treated kd/kd mice showed no significant changes in locomotor activity when tested using the “home cage” activity monitoring system (MedAssociates) in comparison with untreated kd/kd animals (p>0.05). Ambulations are reported as mean +/− S.E.M. (arbitrary units) in 5-minute intervals for a total testing period of 30 minutes. (c) kd/kd mice with dietary probucol supplementation showed no significant changes in performance on the rotarod when compared to untreated kd/kd controls (p>0.05). Data points represent mean +/− S.E.M. for each day of testing, assessment at each timepoint involved three trials per day over three consecutive days. Ages at each timepoint (TP) are as follows: TP1: 17 weeks, TP2: 19 weeks. (d) Probucol treated kd/kd mice showed no significant changes in locomotor activity when tested using the “home cage” activity monitoring system in comparison with untreated kd/kd animals. Ambulations are reported as mean +/− S.E.M. (arbitrary units) in 5-minute intervals for a total testing period of 30 minutes. Statistical analyses were performed using two-way ANOVA followed by Bonferroni-Dunn post-hoc tests. N values denote animal group size.