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. Author manuscript; available in PMC: 2013 Feb 17.
Published in final edited form as: ACS Chem Biol. 2011 Nov 11;7(2):331–339. doi: 10.1021/cb200134p

Figure 1. HDAC class-specific substrates, inhibitors, and compound screen.

Figure 1

a) Structures of class I and class IIa specific substrates. SAHA and dPAHA are used for positive inhibition control of class I HDAC and class IIa respectively (10 μM). b) Orthogonal enzymatic deacetylase activities and inhibition profile of SAHA and dPAHA. c) Typical results for a 96 well plate screen (left panel) and results of 1280 LOPAC screen hits. Compounds which exhibited greater than 40% HDAC inhibition at 10 μM are consider a positive hit from the primary screen (right panel).