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. Author manuscript; available in PMC: 2013 Feb 17.
Published in final edited form as: ACS Chem Biol. 2011 Nov 11;7(2):331–339. doi: 10.1021/cb200134p

Figure 3. Induction of acetylated protein in more complex cellular context.

Figure 3

a) AML cells, MV4-11, were treated with 10 μM concentration of each compound. The acetylation levels were assessed for acetylated tubulin (Ac-Tub), acetylated histone H3 (Ac-HH3), and acetylated histone H4 (Ac-HH4). Selective induction of hyperacetylated tubulin was observed indicating inhibition of HDAC6. b) Concentration dependent hyperacetylation of acetylated tubulin without increases in acetylated histone H3 and H4.