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. Author manuscript; available in PMC: 2013 Feb 17.
Published in final edited form as: ACS Chem Biol. 2011 Nov 11;7(2):331–339. doi: 10.1021/cb200134p

Figure 4. Selective HDAC6 inhibition of naphthoquinone analogs.

Figure 4

a) Inhibition profiles of naphthoquinone analogs. b) Concentration dependent induction of acetylated tubulin in AML MV4-11 cells. c) NQN-1 selectively induces hyperacetylated tubulin without an increase in acetylated histone level. SAHA (class I HDAC and HDAC6 inhibitor) induces both acetylated tubulin and histone, HDAC inhibitor 106 (HDAC3 selective inhibitor) only induces hyperacetylated histone H3/H4.