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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: J Immunol. 2012 Jan 30;188(5):2065–2069. doi: 10.4049/jimmunol.1103282

Figure 1. The LPS-driven proliferative defect of B cells from RP105−/− mice is recapitulated in marginal zone B cells.

Figure 1

(a) Mice were challenged i.p. with LPS (40 μg), and splenic B cell proliferation was quantified by BrdU incorporation 48 h later. Means +/− SE are depicted; N=10 mice/genotype, pooled from 2 independent experiments. *P<0.005; unpaired, two-tailed t test. (b) FACS-sorted MZ B cells were stimulated as indicated, and proliferation was quantified by thymidine incorporation. Means +/− SE of triplicate cultures are depicted; N=4 pooled mice/genotype; representative of 2 separate experiments. *P<0.0001, unpaired, two-tailed t test.