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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: J Comput Neurosci. 2011 Oct 5;32(3):499–519. doi: 10.1007/s10827-011-0366-4

Figure 11.

Figure 11

(A) Firing patterns of subthalmic nucleus (STN), globus pallidus externa (GPe), globus pallidus interna (GPi) and thalamic (TH) cells during activation of GPi local cells (LCs) and GPe fibers of passage (FOPs) during 130 Hz GPi-DBS. Examples from one neuron in each cell group are shown. Black bar indicates duration stimulation was applied. Errors made by the thalamic cell are indicated: misses (*), bursts(+) and spurious events (^). (i) High frequency stimulation of GPi LCs resulted in regularized firing of only GPi neurons. Regularized GPi firing in turn improved thalamic fidelity. (ii) High frequency stimulation of GPe FOPs caused silencing of both STN and GPi neurons due to inhibitory connections from GPe to the STN and GPi. A virtual lesion in the GPi resulted in greater fidelity of thalamic transmission. (B) Error index with total percentage of GPi LC and GPe FOP activation. Results for activation of only GPi LC (△) and only GPe FOP (□) are highlighted. Error index decreased with an increase in activation of GPi LCs, GPe FOPs, and a combination of LCs and FOPs. Total percentage activation of STN LCs and GPi FOPs was strongly correlated with improvements in thalamic fidelity. (C) Error index with different activation ratios of GPi LC to GPe FOP. Results for 50% GPi LC activation (○) and 50% GPe FOP activation (x) are highlighted as examples. Multiple ratios gave equivalent error indexes, resulting in no correlation between the ratio of LC to FOP activation and improvement in thalamic fidelity.