Table 1.
Growth, body and organ weights In rats treated with PCB 126 compared to the corn oil control group two weeks after injection (upper) or at different time points after receiving a total of 2 umol/kg PCB126
|
Dose-Response PCB126 (μmol/kg) |
Body weight gain (%) | Final body weight (g) | Final liver weight (g) | Liver/body weight (%) |
|---|---|---|---|---|
| Corn oil | 26.1 ±1.0 | 325 ±11 | 13.2 ±0.2 | 4.1 ±0.1 |
| 1 | 21.5 ±5.9 | 312 ±8a | 19.3 ±1.1a | 6.2 ±0.4a |
| 5 | −8.1 ±0.4a,b | 225 ±10a,b | 14.0 ±0.6 | 6.3 ±0.1a |
|
| ||||
|
Time-Course Time after injection |
Body weight gain (%) | Final body weight (g) | Final liver weight (g) | Liver/body weight (%) |
|
| ||||
| Corn oil – 1 week | 21.3 ±2.0 | 209 ±7 | 9.3 ±0.5 | 4.5 ±0.2 |
| PCB126 – 1 week | 8.3 ±0.2a | 195 ±4 | 11.4 ±0.1a | 5.9 ±0.1a |
|
| ||||
| Corn oil – 2 weeks | 55.1 ±1.6 | 268 ±6 | 11.1 ±0.7b | 4.1 ±0.2 |
| PCB126 – 2 weeks | 37.6 ±2.6a | 243 ±2a | 14.9 ±0.4a | 6.1 ±0.1a |
Results are expressed as mean ± SEM (n=3).
Statistically significant differences
a
between PCB 126 and corresponding control, and
b
between low and high dose of PCB 126; P<0.05