Table 3.
TBARS and Antioxidant Capacity: Dose- Response and Time-Course
|
Dose-Response PCB126 (μmol/kg) |
Liver TBARS (nmol/100mg protein) | Serum TBARS (nmol/ml) | Serum Antioxidant Capacity(μmol/l) |
|---|---|---|---|
| Corn oil | 297 ±17 | 3.0 ±0.3 | 723 ±107 |
| 1 | 389 ±14a | 3.7 ±0.2 | 765 ±201 |
| 5 | 305 ±23 | 4.1 ±0.1a | 783 ±94 |
|
| |||
|
Time-Course Time after injection |
Liver TBARS (nmol/100mg protein) | Serum TBARS (nmol/ml) | Serum Antioxidant Capacity(μmol/l) |
|
| |||
| Corn oil – 1 week | 397 ±39 | 6.1 ±0.6 | 881 ±42.9 |
| PCB126 – 1 week | 339 ±58 | 6.9 ±0.2 | 923 ±97.7 |
| Corn oil – 2 weeks | 237 ±32 | 5.9 ±0.2 | 804 ±50.4 |
| PCB126 – 2 weeks | 560 ±93a,b | 5.0 ±0.3b | 763 ±94.3 |
Results are expressed as mean ± SEM (n=3).
Statistically significant differences
a
between PCB 126 and corresponding control, and
b
between 1 and 2 weeks of exposure to PCB 126; P<0.05