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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Ann Hum Genet. 2011 Dec 21;76(2):178–191. doi: 10.1111/j.1469-1809.2011.00694.x

Table 3.

Chromosomal elements that affect FXS repeat instability

Factors Effect on repeat expansion (somatic) Reference
Length repeat increase or decrease expansion (Eichler et al., 1994)
Number of interruptions within the repeat increase repeat stability (Eichler et al., 1996)
CGG repeatpurity of the repeat at the 3′ end decrease stability (Crawford et al., 2000)
5′ position of the first AGG interruption increase stability (Eichler et al., 1995)
Haplotype background of the mutation increase of decrease stability (Kunst and Warren, 1994)
SNP associated with expansion (ss71651738) increase repeat instability (Ennis et al., 2007)