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Creatinine clearance (panel A) and accumulation of exogenous [14C]creatinine (panel B) in male wild-type and Oct1/2(−/−) mice. Data are presented as mean values ± SEM. The number of animals for each group is indicated above the column. * indicates a statistical significant difference compared with wild-type mice (P<0.05, unpaired two-tailed t-test).
