Table 1.

Expression profiles for Eph A class RTKs and ligands in human epithelial malignancies

Eph A Class Family Member	Cancer Type	↑/↓ Relative to Normal Tissue	References
EphA1	Ovarian Colon, Gliobastoma Gastric Pancreatic Hepatocellular	↑ ↓ (↑associated with necrosis) ↑ ↑(associated with tumor size) ↑(associated with angiogenesis)	[77] [53, 55, 56, 78] [79, 80] [81] [82, 83]
EphA2	Breast, Lung, Gastric, Colon, Kidney; Breast Breast Lung (NSCLC) Ovarian Colon Gastric Esophageal Gliobastoma Pancreatic Hepatocellular Prostate Urinary Bladder	↑ (tumor and endothelium) ↑ ↑ (HER2+ samples) ↑(correlates with smoking history, brain metastasis, EGFR somatic mutation); mutation G391R associated with invasion ↑(correlates with MVD) ↑(correlates with MVD) ↑ ↑ ↑(PS897-EphA2) ↑(associated with patient age) ↑ ↑ ↑	[10–12, 14, 84] (Brantley-Sieders et al., in preparation) [15] [66–70] [77, 85] [57, 60] [58, 59, 86] [87, 88] [89–91] [81, 92] [93] [94] [95]
EphA3	Lung (NSCLC) Hepatocellular Glioblastoma Melanoma	↓(and/or mutated) mutated mutated mutated	[[71, 72, 96, 97]; Zhuang et al., submitted] [98] [99] [99]
EphA4	Breast Colon Glioblastoma Pancreatic	↑ ↑(correlates with liver metastases) ↑ ↑(associated with proliferation)	(Brantley-Sieders et al., in preparation) [64] [100] [81, 101]
EphA5	Breast Pancreatic	↓ ↑(associated with prognosis)	[26] [81]
EphA6	Colon Kidney	↓ ↓	[56] [56]
EphA7	Breast Colon Glioblastoma Pancreatic Prostate	↑ ↓ ↑ ↑(associated with prognosis) ↓(promoter hypermethylation)	(Brantley-Sieders et al., in preparation) [54] [102] [81] [103]
EphA8	Colon, Glioblastotma	↓	[56]
Ephrin-A1	Breast, Lung, Gastric, Colon, Kidney Ovarian Gastric Esophageal Melanoma Urinary Bladder Glioblastoma	↑(tumor and endothelium) ↑ ↑ ↑ ↑ ↑ ↓	[10] [77] [58, 86] [87] [104] [95] [91]
Ephrin-A2	Hepatocellular	↑	[105]
Ephrin-A3	Lung	↑	[56]
Ephrin-A5	Ovarian Glioblastoma	↑ ↓	[77] [106]