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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Int J Biochem Cell Biol. 2011 Nov 30;44(3):465–468. doi: 10.1016/j.biocel.2011.11.019

Figure 1.

Figure 1

Known actions of angiotensin II on lung parenchymal cells. On lung fibroblasts, angiotensin II (ANGII) has profibrotic actions on growth factor expression, extracellular matrix synthesis and migration mediated through both AT1 and AT2 receptors. On lung vascular smooth muscle (VSM) cells, ANGII promotes vasoconstriction, growth factor expression and prostaglandin synthesis primarily through AT1 receptors. ANGII is proapoptotic for alveolar lung epithelial cell (AECs). The functions of AT2 receptors on VSM and AECs, if any, are currently unknown. See text for details and references.