Skip to main content
. 2012 Feb 2;3(2):266. doi: 10.1038/cddis.2012.6

Figure 6.

Figure 6

Heterozygosity of CDC73 results in a reduction of EIF4EBP transcript levels in human WBCs. WBCs were collected from healthy volunteers or from patients with HPT-JT (CDC73 heterozygotes) or MEN1 (MEN1 heterozygotes). The expression of transcripts for the indicated isoforms of EIF4EBP was determined by quantitative RT-PCR following 72 h of control culture conditions or serum starvation, as indicated. The same data are presented as scatter dot plots on the left (a, c and e) and histograms on the right (b, d and f). Control, n=43–62 transcript measurements from eight cell harvests from eight normal volunteers. CDC73+/−, n=22–34 transcript measurements from seven cell harvests from five patients. MEN1+/−, n=37–47 transcript measurements from 11 cell harvests from 9 patients. For a–f *P<0.05, **P<0.005; ***P<0.0005 for indicated comparisons, using unpaired Student's t-test