Table 1.

Biometric and echocardiographic parameters of mice fed low or high fat diet for 5 months

Parameter	FVB-LF	FVB-HF	IGF-LF	IGF-HF
Body Weight (g)	24.5 ± 0.6	31.7 ± 0.8*	25.0 ± 0.9	30.6 ± 0.6*†
Heart Weight (mg)	122 ± 5	151 ± 6*	136 ± 6*	157 ± 4*†
Tibial length (mm)	18.1 ± 0.3	18.0 ± 0.2	18.0 ± 0.2	18.0 ± 0.2
Heart/Tibial Length (mg/mm)	6.75 ± 0.27	8.38 ± 0.30*	7.56 ± 0.33*	8.75 ± 0.21*†
Liver Weight (g)	1.34 ± 0.05	1.58 ± 0.04*	1.31 ± 0.03	1.59 ± 0.06*†
Kidney Weight (g)	0.31 ± 0.02	0.42 ± 0.02*	0.33 ± 0.02	0.43 ± 0.02*†
Plasma insulin (ng/ml)	0.18 ± 0.02	4.07 ± 0.43*	0.17 ± 0.03	4.46 ± 0.43*†
HOMA-IR (mmol/l*µU/ml)	0.93 ± 0.09	22.7 ± 2.6*	1.06 ± 0.18	27.4 ± 3.6*†
Triglycerides (mg/dl)	45.5 ± 4.8	104.4 ± 7.0*	47.9 ± 6.0	121.9 ± 14.6*†
Plasma leptin (ng/ml)	1.61 ± 0.23	7.14 ± 0.61*	1.55 ± 0.21	7.23 ± 0.62*†
Plasma IL-6 (pg/ml)	69.9 ± 16.4	157.6 ± 25.5*	77.8 ± 18.9	153.3 ± 15.4*†
Plasma IGF-1 (ng/ml)	100.3 ± 8.8	80.6 ± 5.8*	140.2 ± 8.2*	118.1 ± 12.2#
Cardiac Tissue IGF-1 (ng/g)	113.2 ± 16.9	88.0 ± 9.7*	149.5 ± 15.4*	133.8 ± 18.0
Diastolic blood pressure (mmHg)	78.3 ± 4.9	81.0 ± 3.7	81.9 ± 4.4	79.6 ± 4.6
Systolic blood pressure (mmHg)	108.6 ± 6.5	113.9 ± 3.8	111.1 ± 3.3	113.1 ± 4.2
Heart Rate (bpm)	431 ± 15	432 ± 17	447 ± 23	445 ± 16
Wall Thickness (mm)	0.79 ± 0.04	0.90 ± 0.04*	0.88 ± 0.04	0.89 ± 0.03*
EDD (mm)	2.64 ± 0.10	2.91 ± 0.15*	2.77 ± 0.08	2.98 ± 0.08*†
ESD (mm)	1.36 ± 0.11	1.83 ± 0.15*	1.22 ± 0.10	1.55 ± 0.04*#†
LV Mass (mg)	60.2 ± 5.7	86.7 ± 11.3*	75.0 ± 3.5*	85.3 ± 4.6*
Normalized LV Mass (mg/g)	2.52 ± 0.23	2.76 ± 0.41	3.08 ± 0.22*	2.90 ± 0.17*
Fraction Shortening (%)	48.8 ± 2.9	38.3 ± 1.9*	45.5 ± 3.7	47.8 ± 1.1#

LF = low fat; HF = high fat; EDD = end diastolic diameter; ESD = end systolic diameter; LV = left ventricular. Mean ± SEM, n = 13 mice (8 mice for echocardiography) per group,

^*p < 0.05 vs. FVB-LF group,

^†p < 0.05 vs. FVB-LF group,

^#p < 0.05 vs. FVB-HF group.