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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Nat Chem Biol. 2012 Jan 29;8(3):270–276. doi: 10.1038/nchembio.772

Figure 3. Embryonic function of Ntla-dependent genes.

Figure 3

a, Cellular functions of Ntla-dependent genes that are transcribed during gastrulation (9 hpf) or somitogenesis (16 hpf). b-d, Brightfield and DIC (inset) micrographs depicting notochord phenotypes observed in wildtype embryos or those injected with MOs targeting col8a1a or mnx1 at 1 dpf. e-g, Somite patterning in wildtype embryos or those injected with MOs targeting ntla or mnx1 at 1 dpf. h-m, Expression levels of shha, ihhb, and ptc1 in wildtype embryos and mnx1 morphants at 10 hpf. n-p, Comparison of notochord structures in wildtype embryos and those injected with MOs targeting slc38a8 or znf385b. 1.5-dpf embryos are shown. Embryo orientations: b-g and n-p, lateral view and anterior left; h-m, dorsal view and anterior up. Scale bars: b-d, whole-embryo micrograph, 200 μm; b-d, inset, e-g, and n-p, 50 μm; h-m, 100 μm.