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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Nat Neurosci. 2012 Jan 22;15(3):431–S1. doi: 10.1038/nn.3033

Figure 6. Homer1a deletion reduces audiogenic seizures and corrects open field activity in the Fmr1 KO.

Figure 6

A. The incidence and severity of audiogenic seizures was scored as described in methods. Fmr1 KO mice have an increased seizure score that was reduced in H1a/Fmr1 KO mice. (N = 16, 39, 24, 37 mice for WT, Fmr1 KO, H1a KO and H1a/Fmr1 KO, respectively). B. Open field activity, measured as time spent in the center of a lit open arena was increased in Fmr1 KO mice and reversed to WT levels in the H1a/Fmr1 KO mice. (N = 18, 24, 17, 17 mice for WT, Fmr1 KO, H1a KO and H1a/Fmr1 KO, respectively) *p< 0.05; **p< 0.01; ***p<0.001.