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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2011 Nov 8;47(2):194–206. doi: 10.3109/10409238.2011.630974

Figure 3. Potential model of LGP2 function.

Figure 3

A.) LGP2 may have enzymatic activity capable of remodeling RNA substrates, making them more readily detectable by RIG-I and MDA5, thus serving a positive role in antiviral signaling.

B.) During steady state and initially during virus infection the concentrations of LGP2 may be low, allowing LGP2 to function independently or together with RIG-I and MDA5 to positively regulate signaling, perhaps by remodeling RNA substrates (see 3A). LGP2 is inducible by antiviral stimuli, and accumulation of LGP2 to higher levels would allow it to interact with other proteins (blue box, red oval) to form complexes capable of inhibiting RIG-I- and MDA5-mediated antiviral signaling.

A color version of this figure is available online.