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. Author manuscript; available in PMC: 2013 Feb 15.
Published in final edited form as: Neuroimage. 2011 Dec 1;59(4):3571–3581. doi: 10.1016/j.neuroimage.2011.11.057

Table 2.

Comparison of structural corpus callosum measures between very preterm infants with or without grade III or IV intraventricular hemorrhage (IVH), females and males, and those exposed to postnatal corticosteroid (PCS) or not.

Perinatal variable Mean (SD) Unadjusted β (95% CI)a p Adjusted β (95% CI)b p
Whole CC (mm2)* IVH < III 78.66 (13.80) −16.35 (−28.9, −3.8) 0.01 −14.48 (−28.0, −0.96) 0.04
IVH III/IV 62.31 (13.90)
Female 78.60 (12.70) −1.36 (−6.8, 4.1) 0.6 −1.47 (−7.0, 4.1) 0.7
Male 77.24 (15.50)
No PCS 77.97 (13.54) −0.61 (−10.5, 9.3) 0.9 0.85 (−10.0, 11.7) 0.9
PCS 77.36 (21.39)
Genu (mm2) IVH < III 24.41 (5.44) −9.14 (−14.2, −4.1) 0.001 −9.08 (−14.7, −3.5) 0.002
IVH III/IV 15.27 (8.09)
Female 23.68 (5.32) 0.56 (−1.7, 2.8) 0.6 0.45 (−1.9, 2.8) 0.7
Male 24.24 (6.38)
No PCS 23.77 (5.59) 2.40 (−1.7, 6.5) 0.2 3.03 (−1.5, 7.5) 0.2
PCS 26.17 (8.66)
RB (mm2) IVH < III 10.27 (1.90) −1.66 (−3.4, 0.08) 0.06 −1.34 (−3.2, 0.54) 0.2
IVH III/IV 8.61 (2.41)
Female 10.06 (1.81) 0.26 (−0.49, 1.0) 0.5 0.36 (−0.41, 1.1) 0.4
Male 10.32 (2.07)
No PCS 10.25 (1.88) −1.00 (−2.3, 0.33) 0.1 −0.63 (−2.1, 0.87) 0.4
PCS 9.25 (2.46)
AMB (mm2) IVH < III 8.80 (2.85) −1.81 (−4.4, 0.76) 0.2 −1.51 (−4.2, 1.2) 0.3
IVH III/IV 6.99 (2.47)
Female 8.98 (2.93) −0.51 (−1.6, 0.59) 0.4 −0.60 (−1.7, 0.51) 0.3
Male 8.47 (2.78)
No PCS 8.72 (2.79) 0.20 (−1.8, 2.2) 0.8 0.69 (−1.5, 2.8) 0.5
PCS 8.92 (3.66)
PMB (mm2) IVH < III 6.72 (2.28) −1.50 (−3.5, 0.54) 0.1 −1.28 (−3.4, 0.88) 0.2
IVH III/IV 5.22 (1.16)
Female 7.18 (2.44) −1.02 (−1.9, −0.16) 0.02 −1.11 (−2.0, −0.21) 0.02
Male 6.16 (1.98)
No PCS 6.55 (2.29) 1.35 (−0.21, 2.9) 0.09 1.13 (−0.6, 12.9) 0.2
PCS 7.89 (1.67)
Isthmus (mm2) IVH < III 6.47 (1.84) −0.52 (−2.2, 1.1) 0.5 −0.17 (−2.0, 1.7) 0.9
IVH III/IV 5.95 (1.14)
Female 6.42 (1.79) 0.05 (−0.66, 0.75) 0.9 0.005 (−0.75, 0.76) 0.9
Male 6.47 (1.86)
No PCS 6.42 (1.75) 0.45 (−0.81, 1.7) 0.5 0.43 (−1.0, 1.9) 0.6
PCS 6.87 (2.57)
Splenium (mm2) IVH < III 21.99 (5.42) −2.77 (−7.7, 2.1) 0.3 −2.72 (−7.9, 2.4) 0.3
IVH III/IV 19.22 (5.27)
Female 21.94 (5.10) −0.15 (−2.2, 1.9) 0.9 0.02 (−2.1, 2.1) 0.9
Male 21.79 (5.74)
No PCS 22.21 (5.28) −4.02 (−7.7, −0.33) 0.03 −3.73 (−7.8, 0.39) 0.08
PCS 18.18 (6.07)
Eccentricity IVH < III 0.62 (0.14) 0.03 (−0.10, 0.16) 0.7 0.003 (−0.14, 0.15) 0.9
IVH III/IV 0.65 (0.21)
Female 0.64 (0.14) −0.04 (−0.09, 0.02) 0.2 −0.03 (−0.09, 0.03) 0.3
Male 0.60 (0.14)
No PCS 0.62 (0.15) 0.03 (−0.07, 0.13) 0.5 0.05 (−0.07, 0.16) 0.4
PCS 0.65 (0.12)
Skew (posterior) IVH < III 0.52 (0.07) 0.02 (−0.05, 0.08) 0.6 0.02 (−0.06, 0.09) 0.7
IVH III/IV 0.54 (0.12)
Female 0.52 (0.07) 0.004 (−0.02, 0.03) 0.8 0.006 (−0.02, 0.04) 0.7
Male 0.52 (0.08)
No PCS 0.53 (0.07) −0.07 (−0.12, −0.02) 0.008 −0.08 (−0.14, −0.02) 0.009
PCS 0.46 (0.06)
a

Only other significant variables included in the model,

b

Adjusted for gestational age at MRI as well as other clinically relevant perinatal variables: gestational age at birth, gender, birth weight standard deviation score, bronchopulmonary dysplasia, PCS, infection, IVH, and white matter injury.

*

corrected for cross-sectional area of the intracranial cavity. SD = Standard deviation, CI = Confidence interval, RB = rostral body, AMB = Anterior mid-body, PMB = Posterior mid-body, β = regression coefficient, which indicates the amount of change in the dependent variable for each unit change in the independent variable. Bolded = significant at p <0.01 level (corrected for multiple comparisons).