Skip to main content
. Author manuscript; available in PMC: 2013 Feb 15.
Published in final edited form as: Neuroimage. 2011 Dec 1;59(4):3571–3581. doi: 10.1016/j.neuroimage.2011.11.057

Table 3.

Comparison of diffusion measures within the corpus callosum and sub-regions between very preterm infants with high or low white matter injury (WMI) scores, grade III or IV intraventricular hemorrhage (IVH), or infection.

WMI (CC score excluded) IVH Infection
Mean (SD), mm2 Unadjusteda Adjustedb Mean (SD), mm2 Unadjusteda Adjustedb Mean (SD), mm2 Unadjusteda Adjustedb
Diffusion
measure c 		Low High β
(95% CI)		 p β
(95% CI)		 p < grade
III		 grade
III/IV		 β
(95% CI)		 p β
(95% CI)		 P No Yes β
(95% CI)		 p β
(95% CI)		 p
Whole CC FA 0.32
(0.06)		 0.28
(0.06)		 −0.03
(−0.05, −0.01)		 0.004 −0.03
(−0.05, −0.009)		 0.006 0.30
(0.06)		 0.20
(0.04)		 −0.09
(−0.14, −0.04)		 <0.0005 −0.08
(−0.14, −0.03)		 0.004 0.31
(0.06)		 0.28
(0.06)		 −0.02
(−0.04, −0.002)		 0.04 −0.02
(−0.04, 0.008)		 0.2
λ⊥ (×10−3mm2/s) 1.33
(0.15)		 1.38
(0.15)		 N/A N/A N/A N/A 1.35
(0.15)		 1.48
(0.10)		 0.14
(0.001, 0.27)		 0.05 0.13
(−0.01, 0.28)		 0.07 1.33
(0.13)		 1.38
(0.18)		 N/A N/A N/A N/A
Genu FA 0.34
(0.08)		 0.29
(0.06)		 −0.05
(−0.07, −0.02)		 0.001 −0.04
(−0.07, −0.01)		 0.004 0.32
(0.07)		 0.21
(0.03)		 −0.09
(−0.15, −0.03)		 0.005 −0.09
(−0.16, −0.02)		 0.01 0.32
(0.07)		 0.30
(0.07)		 N/A N/A N/A N/A
λ⊥ (×10−3mm2/s) 1.31
(0.18)		 1.39
(0.15)		 0.07
(0.003, 0.13)		 0.04 0.07
(−0.001, 0.13)		 0.06 1.34
(0.16)		 1.53
(0.26)		 0.16
(0.01, 0.31)		 0.03 0.16
(−0.007, 0.32)		 0.06 1.35
(0.17)		 1.35
(0.16)		 N/A N/A N/A N/A
RB FA 0.21
(0.04)		 0.19
(0.07)		 −0.03
(−0.05, −0.002)		 0.03 −0.02
(−0.05, 0.001)		 0.06 0.20
(0.06)		 0.16
(0.04)		 N/A N/A N/A N/A 0.20
(0.07)		 0.20
(0.05)		 N/A N/A N/A N/A
AMB FA 0.25
(0.04)		 0.21
(0.07)		 −0.04
(−0.06, −0.02)		 <0.0005 −0.04
(−0.06, −0.02)		 0.001 0.23
(0.06)		 0.20
(0.04)		 N/A N/A N/A N/A 0.23
(0.06)		 0.22
(0.05)		 N/A N/A N/A N/A
λ⊥ (×10−3mm2/s) 1.37
(0.15)		 1.46
(0.19)		 0.09
(0.02, 0.16)		 0.01 0.08
(0.01, 0.16)		 0.02 1.41
(0.17)		 1.46
(0.17)		 N/A N/A N/A N/A 1.40
(0.16)		 1.43
(0.02)		 N/A N/A N/A N/A
PMB FA 0.23
(0.05)		 0.20
(0.05)		 −0.03
(−0.05, −0.008)		 0.007 −0.02
(−0.05, −0.002)		 0.04 0.22
(0.06)		 0.18
(0.05)		 N/A N/A N/A N/A 0.21
(0.05)		 0.21
(0.06)		 N/A N/A N/A N/A
λ⊥ (×10−3mm2/s) 1.40
(0.14)		 1.48
(0.18)		 0.08
(0.02, 0.14)		 0.01 0.07
(0.003, 0.13)		 0.04 1.44
(0.16)		 1.47
(0.11)		 N/A N/A N/A N/A 1.44
(0.14)		 1.44
(0.18)		 N/A N/A N/A N/A
Splenium FA 0.42
(0.10)		 0.39
(0.10)		 N/A N/A N/A N/A 0.41
(0.09)		 0.24
(0.10)		 −0.18
(−0.26, −0.09)		 <0.0005 −0.15
(−0.24, −0.05)		 0.002 0.42
(0.09)		 0.37
(0.11)		 −0.05
(−0.09, −0.01)		 0.009 −0.04
(−0.08, 0.001)		 0.05
MD
(×10−3mm2/s)		 1.52
(0.21)		 1.53
(0.25)		 N/A N/A N/A N/A 1.52
(0.23)		 1.66
(0.18)		 N/A N/A N/A N/A 1.48
(0.14)		 1.61
(0.30)		 0.14
(0.05, 0.23)		 0.003 0.12
(0.03, 0.22)		 0.01
λ⊥
(×10−3mm2/s)		 2.27
(0.20)		 2.21
(0.25)		 N/A N/A N/A N/A 2.25
(0.22)		 2.09
(0.19)		 0.29
(0.06, 0.52)		 0.01 0.31
(0.06, 0.56)		 0.02 2.21
(0.17)		 2.28
(0.29)		 0.16
(0.06, 0.27)		 0.002 0.15
(0.03, 0.26)		 0.01
a

Only other significant variables included in the model,

b

Adjusted for gestational age at MRI as well as other clinically relevant perinatal variables: gestational age at birth, gender, birth weight standard deviation score, bronchopulmonary dysplasia, postnatal corticosteroids, infection, IVH, and WMI,

c

Only diffusion values which had significant correlations with perinatal variables are shown. CC = corpus callosum, RB = rostral body, PMB = posterior mid-body, FA = fractional anisotropy, MD = mean diffusivity, λ|| = axial diffusivity, λ⊥ = radial diffusivity, SD = standard deviation, CI = confidence interval, N/A = not applicable (no significant perinatal predictors), β = regression coefficient, which indicates the amount of change in the dependent variable for each unit change in the independent variable. Bolded = significant at p <0.01 level (corrected for multiple comparisons).