Table 4.
Relationships between gestational age at birth and callosal tract volumes: whole corpus callosum (CC) and sub-regions.
| Unadjusted β (95% CI)a | p | Adjusted β (95% CI)b | p | |
|---|---|---|---|---|
| Whole CC | 1.09 (0.65, 1.5) | <0.0005 | 0.98 (0.28, 1.7) | 0.007 |
| Genu | 0.58 (0.28, 0.87) | <0.0005 | 0.54 (0.07, 1.0) | 0.02 |
| RB | 0.41 (0.18, 0.64) | 0.001 | 0.43 (0.07, 0.78) | 0.02 |
| AMB | 0.23 (0.03, 0.44) | 0.03 | 0.30 (−0.03, 0.63) | 0.07 |
| PMB | N/A | N/A | N/A | N/A |
| Isthmus | N/A | N/A | N/A | N/A |
| Splenium | 1.33 (0.85, 1.8) | <0.0005 | 1.30 (0.54, 2.1) | 0.001 |
Only other significant variables included in the model.
Adjusted for gestational age at MRI as well as other clinically relevant perinatal variables: gestational age at birth, gender, birth weight standard deviation score, bronchopulmonary dysplasia, postnatal corticosteroids, infection, intraventricular hemorrhage, and white matter injury. CI = Confidence interval, RB = rostral body, AMB = Anterior mid-body, PMB = Posterior mid-body, N/A = not applicable (no significant perinatal predictors), β = regression coefficient, which indicates the amount of change in the dependent variable for each unit change in the independent variable. Bolded = significant at p <0.01 level (corrected for multiple comparisons).