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. Author manuscript; available in PMC: 2013 Mar 25.
Published in final edited form as: J Pharm Biomed Anal. 2012 Jan 16;62:140–148. doi: 10.1016/j.jpba.2012.01.008

Figure 3.

Figure 3

Preclinical plasma concentration versus time curves for irinotecan, SN38, and SN38-G from preclinical TACE experiments performed on a pig. The porcine model demonstrates a very high irinotecan maximum plasma concentration (Cmax), much higher than the upper limit of quantification for irinotecan (1000 ng/mL). This validates the need for the dilution QC at 5000 ng/mL for irinotecan only.