Table 1.
Selected genes affected by Nup210 depletion in post-mitotic myotubes
| Gene Symbol | Accession Number | Fold-Change | p-Value | Function |
|---|---|---|---|---|
|
UP
| ||||
| Hist1h3d | NM_178204 | 1.99 | 0.0003 | Nucleosome remodeling in cell-cycle |
| Psrc1 | NM_019976 | 1.86 | 8 E-05 | Mitosis progression, spindle dynamics regulation |
| Hgf | NM_178204 | 1.85 | 0.0004 | Proliferation, cell growth, and cell motility |
| Ccnb1 | NM_010427 | 1.62 | 0.0061 | Regulation of cell-cycle |
| Casc5 | NM_024245 | 1.63 | 0.0040 | Spindle assembly and chromosome alignment |
| Mki67 | NM_001081117 | 1.62 | 0.0048 | Cell proliferation |
| Kif11 | NM_001081117 | 1.58 | 0.0158 | Chromosome positioning, centrosome separation and bipolar spindle assembly in mitosis |
| Bub1 | NM_009773 | 1.55 | 0.0118 | Mitotic spindle assembly checkpoint, kinetochore assembly |
| Ccna2 | NM_009828 | 1.54 | 0.0136 | Cell-cycle regulation |
| Knl2 | NM_172578 | 1.54 | Chromosome segregation during mitosis | |
| Kif23 | NM_024245 | 1.54 | 0.0022 | Cell-cycle progression, cytokinesis. |
| Mad2l1 | NM_019499 | 1.53 | 0.0005 | Mitotic spindle assembly checkpoint |
| Parp14 | NM_001039530 | 1.50 | 0.0019 | Survival of injured proliferating cells |
|
| ||||
|
DOWN
| ||||
| Nkd2 | NM_028186 | 2.54 | 0.0004 | Development regulation through Wnt signaling |
| Tmem119 | NM_146162 | 2.19 | 0.0002 | Promotes osteoblast differentiation |
| L1cam | NM_008478 | 2.18 | 5 E-05 | Nervous system development, neuronal migration and differentiation |
| Gpr56 | NM_018882 | 1.95 | 0.0007 | Testis and nervous system development |
| Kpna3 | NM_008466 | 1.90 | 2 E-06 | Development regulation through Wnt signaling, spermatogenesis |
| Neu2 | NM_001160165 | 1.90 | 0.0013 | Myogenic differentiation |
| Grhl3 | NM_001013756 | 1.89 | 0.0021 | Epidermal differentiation |
| Wnt10a | NM_009518 | 1.86 | 0.0014 | Limb development, cartilage and odontoblast differentiation |
| Nefl | NM_010910 | 1.85 | 0.0026 | Nervous system development |
| Ablim3 | NM_198649 | 1.79 | 0.0049 | Embryonic development, cell lineage determination* |
| Ndrg2 | NM_013864 | 1.76 | 0.0128 | Myoblast proliferation and neural differentiation |
| Crim1 | NM_015800 | 1.74 | 0.0011 | Nervous system development |
| Cmklr1 | NM_008153 | 1.74 | 1 E-05 | Regulates adipogenesis and osteoblastogenesis |
| Apobec2 | NM_009694 | 1.73 | 1 E-06 | Stem cell differentiation |
| Mfap5 | NM_015776 | 1.72 | 0.0014 | Angiogenesis |
| Mir145 | NR_029557 | 1.70 | 0.0003 | Growth arrest and differentiation |
| Edn1 | NM_010104 | 1.69 | 0.0004 | Nervous system development |
| Nox4 | NM_015760 | 1.68 | 0.0072 | Myofibroblast, osteoblast and chondrogenic differentiation, angiogenesis |
| Gdf5 | NM_008109 | 1.67 | 0.0007 | Limb morphogenesis, embryonic cell differentiation, skeletal and joint development |
| Stra13 | NM_016665 | 1.66 | 3 E-08 | Satellite cell activation, myogenic and trophoblast differentiation |
| Clic5 | NM_172621 | 1.64 | 0.0018 | Myoblast proliferation and differentiation |
| Igfbp4 | NM_010517 | 1.64 | 0.0115 | Inhibitor of myoblast differentiation |
| Asb2 | NM_177407 | 1.63 | 8 E-05 | Muscle differentiation |
| Camk2a | NM_177407 | 1.63 | 8 E-05 | Nervous system development, osteoblast differentiation |
| Rrad | NM_019662 | 1.59 | 5 E-05 | Stem cell differentiation |
| Tspan12 | NM_173007 | 1.57 | 1 E-05 | Vascular development |
| Cand2 | NM_025958 | 1.56 | 0.0008 | Myogenic differentiation |
| Fam136a | BC103775 | 1.55 | 3 E-05 | Gastrointestinal development |
| Wnt10b | NM_011718 | 1.54 | 0.0026 | Skeletal development, epithelial and osteoblast differentiation, adipogenesis |
| Noxp20 | NM_026667 | 1.53 | 0.0001 | Neuronal differentiation |
| Bmp2k | NM_080708 | 1.5 | 6 E-05 | Osteoblast differentiation |
| Ptprf | NM_011213 | 1.5 | 0.0002 | Adipogenic, thymocite differentiation, nervous system development |