Fig. 2.

(A) Resorption cavities are identified as indentations on the bone surface. The horizontal lines that appear on the reconstructed bone surface correspond to cross-sections during image acquisition. (B) An observer manually traces the resorption cavity (white). (C, D) Maximum Cavity depth is determined by approximating the ‘pre-resorbed’ bone surface above a resorption cavity using a three-dimensional spline (see Methods for a description of the curve fitting). (E) A cross-section of a resorption cavity with the ‘pre-resorbed’ surface applied is shown. Cavity depth was measured as the maximum distance between the ‘pre-resorbed’ surface and the eroded surface (dashed line).