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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Nat Neurosci. 2012 Jan 15;15(3):406–S2. doi: 10.1038/nn.3025

Figure 4.

Figure 4

The GluN2 S/L site contributes to NMDAR subtype specificity of relative Ca2+ permeability. (a,b) Representative I–V curves in 143 mM extracellular Cs+ (a) and 1.8 mM extracellular Ca2+ (b). (c,d) Average Vrevs, ± s.e.m., of wild-type and mutant NMDARs in 143 mM extracellular Cs+ (c) and 1.8 mM extracellular Ca2+ (d). (c) No significant differences were detected among wild-type and mutant receptor Vrevs in 143 mM extracellular Cs+ (one-way ANOVA, p = 0.63). (d) Significantly different Vrevs (one-way ANOVA, p < 0.05) between wild-type and mutant receptors are marked with an asterisk. (e) PCa/PCs values of wild-type and mutant NMDARs.