Figure 6.

Influence on Mg²⁺ inhibition of mutations at the GluN2 S/L site. (a) Voltage-dependence of Mg²⁺ IC₅₀s of NMDARs containing wild-type GluN2A subunits, wild-type GluN2D subunits, or GluN2A subunits mutated at the GluN2 S/L site. (b) Mg²⁺ IC₅₀s of wild-type and mutant NMDARs at −75 mV. Examination of correlations between amino acid properties and Mg²⁺ IC₅₀s can be found in Supplementary Figure 3.