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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Acta Neuropathol. 2011 Dec 11;123(3):321–348. doi: 10.1007/s00401-011-0928-6

Fig. 9.

Fig. 9

A schematic demonstrating the cycling of merlin between its active (dephosphorylated) and inactive (phosphorylated) configurations and how this activity affects major cytoplasmic signaling pathways important to Schwann cell biology. Note that different intramembranous receptors can inactivate [e.g. receptor tyrosine kinase (RTK) complexes] or activate (cadherins, CD44) merlin by activating kinases [protein kinase A (PKA), p21-activated kinase (Pak)] that phosphorylate merlin or phosphatases (MYPT1) that remove phosphate groups.