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. Author manuscript; available in PMC: 2013 Feb 17.
Published in final edited form as: ACS Chem Biol. 2011 Nov 17;7(2):367–377. doi: 10.1021/cb2004274

Figure 3. Mechanism of action (MOA) and inhibition studies of compound 1 with HePTP and HePTP mutants.

Figure 3

(a) Progress curves of HePTP activity in the presence of different doses of compound 1. No time-dependent inhibition was observed as demonstrated by the linear progress curves of the HePTP phosphatase reaction. (b) Eadie-Hofstee plot of the Michaelis-Menten kinetic studies with compound 1. (c) Dose-response curves for compound 1 with either wt HePTP, HePTP-DM, or HePTP H237A.

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