Table 1.

SAR and selectivity analysis for compound 1 and analogs (IC₅₀ values in μM).

Cmpd #	PubChem CID	Structure	HePTP	MKP-3	VHR	STEP	PTP-SL	PTP1B	LYP	TCPTP	SHP1	SHP2	CD45	LAR
1*	1357397*		0.21	5.2	1.9	6.3	1.1	1.7	1.9	1	2.5	1.1	3.1	73
2	5341943		1.8	17	5.8	~100	20	28	30	n/d	n/d	n/d	n/d	n/d
3	5341934		4.9	57	12	>100	41	~100	~100	n/d	n/d	n/d	n/d	n/d
4	2300608		5.7	>100	8.8	>100	~100	>100	>100	n/d	n/d	n/d	n/d	n/d
5	2258411		35	>100	>100	>100	>100	>100	>100	n/d	n/d	n/d	n/d	n/d
6	n/a		>100	>100	>100	>100	>100	>100	>100	n/d	n/d	n/d	n/d	n/d

^*Compound 1 was submitted as a probe to the Molecular Libraries Probe Production Centers (MLPCN) and has the Probe ML# ML119.