Table 3.
Brain regions (ROIs) where the BOLD response was (a) greater in all IBS patients (n=33) than in healthy controls (n=18) (b) in hypersensitive IBS patients (n=15) than in normosensitive IBS patients (n=18)
| (a) IBS > controls | ||||||
|---|---|---|---|---|---|---|
| ROI | cluster size |
peak p(FWE) |
X- coord |
Y- coord |
Z- coord |
|
| 45 mmHg distension | ||||||
| VLPFC | L | 21 | 0.05 | −40 | 16 | −18 |
| 15 mmHg distension | ||||||
| insula mid | L | 59 | 0.04 | −40 | −8 | −8 |
|
Expectation of 45 mmHg
distension |
||||||
| insula anterior ventral | R | 10 | 0.04 | 32 | 22 | −14 |
| insula mid | R | 45 | 0.03 | 40 | −6 | −12 |
| hippocampus | R | 25 | 0.03 | 26 | −38 | 0 |
|
Expectation of 15 mmHg
distension |
||||||
| No significant findings | ||||||
| (b) Hypersensitive > normosensitive | ||||||
|---|---|---|---|---|---|---|
| ROI | cluster size |
peak p(FWE) |
X- coord |
Y- coord |
Z- coord |
|
| 45 mmHg distension | ||||||
| insula posterior | L | 69 | 0.02 | −34 | −26 | 6 |
| DLPFC | R | 345 | 0.04 | 22 | 48 | 8 |
| aMCC | R | 68 | 0.04 | 8 | 40 | 16 |
| pACC | L | 210 | 0.04 | −10 | 50 | 16 |
| pACC | R | 309 | 0.01 | 18 | 50 | 12 |
| 15 mmHg distension | ||||||
| No significant findings | ||||||
|
Expectation of 45 mmHg
distension |
||||||
| insula posterior | R | 71 | 0.01 | 36 | −14 | 20 |
| thalamus | R | 119 | 0.05 | 14 | −26 | 6 |
|
Expectation of 15 mmHg
distension |
||||||
| insula anterior ventral | R | 29 | <0.01 | 46 | 18 | −6 |