Production of cytokines (A) and chemokines (B) in the spinal cord from MOG35–55 immunized Wt mice, Wt mice injected with rGMF, GMF-KO mice and GMF-KO mice reconstituted with rGMF. Cytokine/chemokine concentrations were measured by quantitative ELISA in samples obtained from Wt mice (20 days post immunization, clinical score 3), Wt mice following rGMF administration (19 days post immunization, clinical score 4), GMF-KO mice (26 days post immunization, clinical score 1.5), and GMF-KO mice following rGMF administration (22 days post immunization, clinical score 3).