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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Pain. 2012 Jan 13;153(3):704–709. doi: 10.1016/j.pain.2011.12.011

Fig. 3.

Fig. 3

Effects of oligomycin on chemotherapy-evoked abnormal spontaneous discharge in primary afferent axons in paclitaxel-treated and oxaliplatin-treated rats. Baseline discharge frequency (dashed line) was computed from the discharge rate seen in a 5 min epoch prior to injection and is set at 100%. (A) Effects on A-fibers after injection of oligomycin (paclitaxel-treated and oxaliplatin-treated rats, 10 fibers each) or vehicle (10 fibers; 5 each from paclitaxel-treated and oxaliplatin-treated rats) at time zero. (B) Effects on C-fibers after injection of oligomycin (paclitaxel-treated and oxaliplatin-treated rats, 7 fibers each) or vehicle injection (10 fibers; 5 each from paclitaxel-treated and oxaliplatin-treated rats). The oligomycin-evoked changes are statistically significant (p < 0.05) for both the paclitaxel-treated and oxaliplatin-treated A-fibers and C-fibers (ANOVA on the area-under-the-curve values followed by Dunnett’s t-test). The mitochondrial poisons, rotenone, oligomycin, and auranofin, significantly increase chemotherapy-evoked neuropathic pain at doses that have no effect on the responses of normal rats.