Figure 5. SAMHD1 degradation by some Vpr proteins preceded the birth of Vpx.
The phylogeny shown in Figure 2A was rooted to common ancestor of SIVolc/SIVwrc, as determined by the phylogenetic positioning of the flanking pol and env genes in relation to pSIVgml (Figure S4), and is consistent with previous reports that the Colobinae SIVs are outgroup to the Cercopithecinae SIVs (Gifford et al., 2008; Gilbert et al., 2009; Liégeois et al., 2009). Important nodes that infer ancestral traits are boxed in numbers.
