Table 1.
Arthritis Severity Scores for DA and Cia3 congenic and subcongenic rats.
| Model | Strain | n | ASI 1 |
P-value 2 | ASI reduction | ||
|---|---|---|---|---|---|---|---|
| median | 25% | 75% | |||||
| PIA | DA | 55 | 95.0 | 43.0 | 144.5 | ||
| Cia3 | 19 | 18.0 | 16.0 | 26.0 | ≤ 0.001 | 81.1% | |
| Cia3a | 26 | 46.0 | 32.3 | 57.8 | ≤ 0.001 | 51.6% | |
| Cia3b | 26 | 49.5 | 36.3 | 66.5 | 0.003 | 47.9% | |
| Cia3d | 46 | 38.5 | 23.5 | 54.8 | ≤ 0.001 | 59.5% | |
| Cia3f | 13 | 33.0 | 31.0 | 43.0 | 0.002 | 65.3% | |
| Cia3g | 14 | 54.0 | 35.5 | 70.3 | 0.031 | 43.2% | |
| CIA | DA | 21 | 265.0 | 210.0 | 342.0 | --- | |
| Cia3 | 19 | 40.0 | 31.0 | 87.5 | ≤ 0.001 | 84.9% | |
| Cia3a | 19 | 56.0 | 20.5 | 107.0 | ≤ 0.001 | 78.9% | |
| Cia3d | 20 | 64.5 | 40.8 | 112.8 | ≤ 0.001 | 75.7% | |
| Cia3g | 9 | 47.0 | 28.0 | 139.0 | ≤ 0.001 | 82.3% | |
1
Arthritis Severity Index (sum of arthritis scores obtained over time).
2
Mann-Whitney test (comparisons versus DA)