Skip to main content
. Author manuscript; available in PMC: 2013 Mar 14.
Published in final edited form as: Chem Rev. 2011 Oct 21;112(3):1681–1709. doi: 10.1021/cr200073d

Scheme 11.

Scheme 11

The cyclopropane-containing natural products FR-900848 (74) and U-106305 (75) are likely biosynthesized by a series of insertion of a SAM-derived methylene group into each of the reacting alkene moiety.