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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Front Neuroendocrinol. 2011 Nov 4;33(1):85–104. doi: 10.1016/j.yfrne.2011.10.001

Figure 10. Long-term E2 deprivation leads to hypersensitivity of CA3/CA4 neurons to ischemic cell death following 10 min of global cerebral ischemia, and E2 replacement is incapable of exerting neuroprotection or reversing the CA3/CA4 hypersensitivity to ischemic damage.

Figure 10

Typical microscopy images showing NeuN staining in hippocampus from Sham or Placebo (Pla)-treated Imm (immediate) or 10W (10 week) ovariectomized rats. Note the increased sensitivity of the CA3/CA4 region in Pla 10W animals to neuronal cell death, as evidenced by loss of NeuN staining. Magnification is 5× and the scale bar = 200 μm. Adapted from [203].