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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Front Neuroendocrinol. 2011 Nov 4;33(1):85–104. doi: 10.1016/j.yfrne.2011.10.001

Figure 3. Estradiol Induces Expression of Survivin in CA1 Hippocampal Neurons 24 and 48 Hours After Global Cerebral Ischemia.

Figure 3

(A, B) 17β-Estradiol enhances expression of the anti-apoptotic protein survivin in hippocampus CA1 after global cerebral ischemia. Values are mean ± SEM of determinations from five to six individual rats expressed as fold change versus sham control. Pla, Placebo; R, reperfusion. *P < 0.05 versus sham control; #P < 0.05 versus the Pla group at the same time point. (C) DAB and confocal analysis shows that survivin is induced in NeuN-positive neurons by E2 in hippocampus CA1 at 24 h after global cerebral ischemia. Results are representative of staining observed in five individual animals per group (magnifications, 40×). Scale bars, 50μm. Figure adapted from [204].

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