Table 3.

Comparison of Discrimination and Reclassification Indices^*

	C-statistic	95% CI	p†	IDI (%)	p†	NRI (%)	p†
Clinical Model‡	0.695	0.652–0.738	--	--	--	--	--
Biochemical Markers
Clinical Model+UACR	0.706	0.664–0.749	0.168	0.44	0.139	3.03	0.475
Clinical Model+HbA1c	0.714	0.673–0.755	0.044	0.95	0.021	5.00	0.241
Clinical Model+HbA1c+UACR	0.717	0.675–0.758	0.056	1.20	0.009	1.45	0.770
(vs. Clinical Model+HbA1c)	--	--	0.575	0.29	0.229	−2.61	0.507
Echocardiographic Measures
Clinical Model+LA Diameter	0.701	0.657–0.744	0.528	0.90	0.004	0.84	0.821
Clinical Model+MAC	0.698	0.655–0.742	0.444	0.13	0.592	1.18	0.661
Clinical Model+LA Diameter+MAC	0.703	0.659–0.748	0.368	1.01	0.004	2.11	0.595
Biochemical and Echocardiographic Measures
Clinical Model+LADiameter+HbA1c	0.716	0.673–0.759	0.101	2.33	<0.001	4.82	0.348
(vs. Clinical Model+HbA1c)	--	--	0.767	1.81	<0.001	−1.56	0.735
Clinical Model+LA Diameter+	0.719	0.675–0.762	0.105	2.26	0.001	6.64	0.215
HbA1c+UACR
(vs. Clinical Model+HbA1c)	--	--	0.639	1.74	<0.001	5.33	0.274
(vs. Clinical Model+HbA1c+UACR)	--	--	0.822	1.05	0.003	3.22	0.459
Clinical Model+LA Diameter+MAC+HbA1c	0.718	0.674–0.761	0.092	2.41	<0.001	6.19	0.233
(vs. Clinical Model+HbA1c)	--	--	0.676	1.89	<0.001	5.40	0.255
Clinical Model+LA Diameter+MAC+UACR+HbA1c	0.720	0.676–0.763	0.093	2.81	<0.001	6.65	0.219
(vs. Clinical Model+HbA1c+UACR)	--	--	0.731	1.60	<0.001	3.72	0.407
(vs. Clinical Model+HbA1c+LA Diameter)	--	--	0.533	0.47	0.147	2.46	0.434
(vs. Clinical Model+LA Diameter+MAC+HbA1c)	--	--	0.632	0.40	0.098	0.37	0.892

All indices are for continuous variables except for MAC.

^*For C-statistics, all values calculated in subset with available data for all biochemical and echocardiographic measures (n=2286). For IDI and NRI, all values calculated in subsets with available data for all biochemical markers (n=2306), all echocardiographic measures (n=2371), or both (n=2286), depending on the comparisons.

^†Compared to basic clinical model, unless otherwise indicated.

^‡See Model 2, Table 2